Aging-Related Alterations of Subtelomeric Methylation in Sarcoidosis Patients
نویسندگان
چکیده
منابع مشابه
The gender-related alterations in the telomere length and subtelomeric methylation status in patients with Parkinson’s disease
The aim of this study was to determine whether Parkinson’s disease affects somatic telomeric features. Some recent reports have shown that telomere length is not changed in patients with Parkinson’s disease (PD). In this study, we more closely evaluated possible Parkinson’s disease-associated telomeric alterations than has been done previously. We analyzed the telomere length distribution, the ...
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Objective The Subtelomeric rearrangements are increasingly being investigated in cases of idiopathic intellectual disabilities (ID) and congenital abnormalities (CA) but have also been suspected to be responsible for unexplained recurrent miscarriage (RM). We have noticed a higher risk of subtelomeric translocations in association with CA and ID. Such rearrangements can go unnoticed through con...
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Thirty patients with bilateral lymph node enlargement with or without parenchymal infiltrates on the chest x- ray suspected to have sarcoidosis were studied between June 1980 and December 1989 in our institution. Eleven of these patients who were free of parenchymal infiltrates did not have a biopsy performed and the diagnosis of sarcoidosis was made based on self-limited regression and cl...
متن کاملOptogenetic regulation of site-specific subtelomeric DNA-methylation
Telomere length homeostasis, critical for chromosomal integrity and genome stability, is controlled by intricate molecular regulatory machinery that includes epigenetic modifications. Here, we examine site-specific and spatiotemporal alteration of the subtelomeric methylation of CpG islands using optogenetic tools to understand the epigenetic regulatory mechanisms of telomere length maintenance...
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ژورنال
عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
سال: 2009
ISSN: 1079-5006,1758-535X
DOI: 10.1093/gerona/glp049